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Ketamine topical gel

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Ketamine Topical Gel

KETAMINE TOPICAL GEL

 

 

 KETAMINE TOPICAL GEL


Ketamine Topical Gel is one of the products compounded in our own pharmacy. Ketamine Gel may provide clinicians with a new option in the battle against chronic neuropathic pain. Neuropathic pain is often resistant to opioids, so other medication classes, such as tricyclic antidepressants, anticonvulsants, and local anesthetics, are often used. Central sensitization, or pain 'wind-up', may perpetuate chronic neuropathic pain even when ongoing peripheral sensory input is absent. Wind-up is thought to cause allodynia, hyperalgesia, and hyperpathia. Receptors such as NMDA, AMPA, and M-glu have recently been identified for their role in central sensitization or pain 'wind-up'. Ketamine has been proposed recently for neuropathic pain secondary to its NMDA receptor activity. The current application as a topical gel stems from the theory that ketamine has peripheral action at both opioid and Na+-K+ channels.

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