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SUPPORTING
LITERATURE
:
Low Free
Testosterone as a
Potentially
Treatable Cause of
Depression in Older
Men
Arch Gen Psychiatry.
2008 Mar;65(3):283-9
Low free
testosterone
concentration as a
potentially
treatable cause of
depressive symptoms
in older men.
In order to access the
PubMed abstract of this
article, visit this
website link.
Low
Testosterone
Increases Mortality
Risk in Men
A population-based
cohort study
followed 1954 men
aged 20 to 89 years
for an average of
7.2 years, and has
demonstrated a link
between low levels
of testosterone and
increased risk for
mortality in adult
men of all ages.
http://www.medscape.com/viewarticle/576267
(accessed 10/08)
Administration of a
transdermal
testosterone (T) gel
formulation to
hypogonadal men
provided
dose-proportional
increases in serum T
levels to the normal
adult male range.
Testosterone 1% gel
(50 or 100 mg/day)
was compared to the
permeation-enhanced
T patch. After 180
days, skin
irritation was
reported in 5.5% of
subjects treated
with T gel and in
66% of subjects in
the
permeation-enhanced
T patch group. This
research at UCLA
concluded that T gel
replacement improved
sexual function and
mood, increased lean
mass and muscle
strength
(principally in the
legs), and decreased
fat mass in
hypogonadal men with
less skin irritation
and discontinuation
compared with the
recommended dose of
the
permeation-enhanced
T patch.
J Clin
Endocrinol Metab.
2000
Aug;85(8):2839-53
Transdermal
testosterone gel
improves sexual
function, mood,
muscle strength, and
body composition
parameters in
hypogonadal men.
In order to access the
PubMed abstract of this
article, visit this
website link.
The below mentioned study
concluded that
replacing
testosterone in hypogonadal men
increases bone
mineral density of
the spine and hip,
fat-free mass,
prostate volume,
erythropoiesis,
energy, and sexual
function. The full
effect of
testosterone on bone
mineral density took
24 months, but the
full effects on the
other tissues took
only 3-6 months.
J Clin
Endocrinol Metab
2000
Aug;85(8):2670-7
Effects of
testosterone
replacement in
hypogonadal men.
In order to access the
PubMed abstract of this
article, visit this
website link.
Am J Med 2001
May;110(7):563-72
Hypogonadism
and androgen
replacement therapy
in elderly men.
In order to access the
PubMed abstract of this
article, visit this
website link.
Drugs Aging
1999
Aug;15(2):131-42
Risks versus
benefits of
testosterone therapy
in elderly men.
In order to access the
PubMed abstract of this
article, visit this
website link.
The findings below
suggest that low
levels of
testosterone and SHBG play some role
in the development
of insulin
resistance and
subsequent type 2
diabetes.
Diabetes Care 2000
Apr;23(4):490-4
Testosterone, sex
hormone-binding
globulin, and the
development of type
2 diabetes in
middle-aged men:
prospective results
from the
Massachusetts male
aging study.
In order to access the
PubMed abstract of this
article, visit this
website link.
Manifestations of
testosterone
deficiency have
included depression,
anxiety,
irritability,
insomnia, weakness,
diminished libido,
impotence, poor
memory, reduced
muscle and bone
mass, and diminished
sexual body hair.
Although
testosterone levels
decline with age,
there is great
interindividual
variability.
Am J Psychiatry 1998
Oct;155(10):1310-8
Age-associated
testosterone decline
in men: clinical
issues for
psychiatry.
In order to access the
PubMed abstract of this
article, visit this
website link.
Massive obesity in
males is associated
with decreased total
and free
testosterone levels
as well as elevated
estradiol levels.
Med Hypotheses 1999
Jan;52(1):49-51
The
hypogonadal-obesity
cycle: role of
aromatase in
modulating the
testosterone-estradiol
shunt-a major factor
in the genesis of
morbid obesity.
In order to access the
PubMed abstract of this
article, visit this
website link.
These results
suggest that
testosterone
treatment might
improve depressed
mood in older men
who have low levels
of bioavailable
testosterone.
J Clin
Endocrinol Metab
1999 Feb;84(2):573-7
Bioavailable
testosterone and
depressed mood in
older men: the
Rancho Bernardo
Study.
In order to access the
PubMed abstract of this
article, visit this
website link.
The following
results suggest that
until the age of 60
years, the mean
serum level of DHEAS
is lower in patients
with ED than in
healthy volunteers.
Urology 2000
May;55(5):755-8
Serum
dehydroepiandrosterone
sulfate
concentrations in
men with erectile
dysfunction.
In order to access the
PubMed abstract of this
article, visit this
website link.
Sublingual
sildenafil in the
treatment of
erectile
dysfunction: faster
onset of action with
lower dose
Forty
consecutive patients
with erectile
dysfunction (mean
age was 55 years)
for more than three
months were included
in this study.
Sixty-five percent
of patients (13/20)
who received
sublingual
sildenafil achieved
satisfying erections
and coitus, whereas
the rate was 15% in
the placebo group
(3/20). The mean
onset of action with
sublingual
sildenafil was 15.5
minutes and lasted
for an average of 40
minutes. Minimal
headaches, sweating
and flushing were
noted as the
side-effects.
The conclusion: "20
mg sublingual
sildenafil is safe
and effective in the
treatment of
erectile
dysfunction.
Sublingual
administration has
some advantages as
it is not effected
by food ingestion
and quickly appears
in the circulation.
These advantages
provide a faster
onset of action with
a lower dose when
compared to oral
sildenafil.
Sublingual use of
sildenafil may be
more cost-effective
and possibly
provides a more
predictable onset of
action."
Int J Urol. 2004
Nov;11(11):989-92
Sublingual
sildenafil in the
treatment of
erectile
dysfunction: faster
onset of action with
less dose.
In order to access the
PubMed abstract of this
article, visit this
website link.
The
International
Journal of
Pharmaceutical
Compounding
[March/April
2007;11(2):121]
reported a formula
for Sildenafil 20mg
Troches (flavored)
with a recommended
beyond-use date of
180 days.
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